PH-RESPONSIVE TARGETED NANOPARTICLES RELEASE ERK-INHIBITOR IN THE HYPOXIC ZONE AND SENSITIZE FREE GEMCITABINE IN MUTANT K-RAS-ADDICTED PANCREATIC CANCER CELLS AND MOUSE MODEL.

Therapeutic options for managing Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types of aggressive malignancies, are limited and disappointing.Therefore, despite suboptimal clinical effects, gemcitabine (GEM) remains the first-line chemotherapeutic drug in the clinic for PDAC treatment.The therapeutic limitations of GEM are primaril

Rice false smut, a fungal disease caused by Ustilaginoidea virens is becoming a severe detriment to rice production worldwide.However, little is known about the molecular response of rice to attacks by the smut pathogen.In this article, we define the initial infection process as having three stages: initial colonization on the pistil (stage 1, S1),

Consumers purchasing textiles usually feel fabrics for its tactile properties indicating that they are interested in comfort properties rather than other properties.During daily activities, low-stress mechanical action like bending, shear, compression, tensile, and hysteresis occurs on clothing.These high sensitive low-stress mechanical properties

Deepening the reform of the cultural system and promoting the all-round prosperity of cultural undertakings edgewater shoes and the rapid development of the cultural industry are vital to the realization of the goal of building a moderately prosperous society in an all-round way, to the overall layout of the cause of socialism with Chinese characte